--- title: Are Liquid Filled Capsules the Right Delivery Method for Your Formula? description: Liquid filled capsules are more adaptable to different types of filling, in fact,they are one of the most common methods of drug delivery. 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CapsCanada is now Lyfe Group. We have a new image, but the same team, products and quality as always. | CapsCanada is now Lyfe Group. We have a new image, but the same team, products and quality as always. | CapsCanada is now Lyfe Group. We have a new image, but the same team, products and quality as always. | CapsCanada is now Lyfe Group. We have a new image, but the same team, products and quality as always. | CapsCanada is now Lyfe Group. We have a new image, but the same team, products and quality as always. | CapsCanada is now Lyfe Group. We have a new image, but the same team, products and quality as always. | CapsCanada is now Lyfe Group. We have a new image, but the same team, products and quality as always. | CapsCanada is now Lyfe Group. We have a new image, but the same team, products and quality as always. | CapsCanada is now Lyfe Group. We have a new image, but the same team, products and quality as always. | ![Liquid filled capsules formula](https://blog.lyfegroup.com/hubfs/45-portada-768-x-300%20(1).jpg "Liquid filled capsules formula") - [LQ-CAPS®](https://blog.lyfegroup.com/tag/LQ-CAPS) # Are Liquid Filled Capsules the Right Delivery Method for Your Formula? Posted by [CapsCanada](https://blog.lyfegroup.com/author/capscanada) on Oct 12, 2021, 10:01:46 a.m. As the pharmaceutical market continues to develop new and different formulas, delivery methods also evolve . According to data,[over 25% of drugs that are currently in the development stage contain highly potent Active Pharmaceutical Ingredients (APIs](https://www.americanpharmaceuticalreview.com/Featured-Articles/358689-Liquid-Fill-Capsules-Benefits-for-Highly-Potent-API-Formulation-and-Scale-Up/)). The main challenge? Developing these formulations into effective low-dose medicines. A potential answer? Liquid filled capsules, since they offer a more accurately dosed and homogeneous formulation. In fact, liquid filled capsules are one of the most common methods of drug delivery. They are composed of two hard capsule pieces that are specially designed for use with liquids and semi-solids. Liquid filled capsules are known for their improved stability, dosage form flexibility and need for fewer  required stability studies. Unlike softgels, which are known for their use in oil-based formulations, liquid filled capsules are more adaptable to different types of fillings, thereby meeting a wider range of product requirements. Plus,  softgels contain glycerin and sorbitol, components that[may affect the consumer](https://www.pharmaceutical-business-review.com/products/licaps-liquid-filled-capsules/). Meanwhile, liquid filled capsules are starch-free, gluten-free, and free of  additives and preservatives.    ## **Additional benefits associated with liquid filled capsules**   Other reasons for liquid filled capsules’ popularity include:  - **This dosage form can generate high potency oral products in less time, reducing your formula’s time to market.** - **Liquid filling can provide homogeneity for low dose products, through the generation of a solution, even if your formula has a limitation.** - **Liquid filling makes the capsule filling process safer for highly-potent APIs because the integration of API powders into the liquid excipient eliminates the risk of exposure for the machine operators.**   ### **Benefits for your formula**   - Improved absorption,[bioavailability](https://pharma-trends.com/2020/11/12/liquid-filled-hard-gelatin-capsules-revitalising-pharmaceuticals/), and stability - Sustained release of the components - Ease of coating - Less gas transmission - Dosage form flexibility - Wide regulatory acceptance - No transition from clinical to market capsules   ### **To keep in mind**    As you are evaluating this option, it is important to understand some characteristics of liquid filled capsules. First, like traditional hard capsules, liquid filled capsules are made of gelatin obtained from bovine bone, hide, and skin collagen. Vegetarian options, such as capsules made from  hydroxypropyl methylcellulose (HPMC), are also available. Second, liquid filled formulations require excipients such as lipophilic liquid or semisolid vehicles, solubilizing agents, surfactants, and emulsifying agents. Thus, there are a few considerations to keep in mind: - **The fill material must be chemically inert.** - **You must verify that the fill material is compatible with the gelatin capsule you are going to use.** - **Liquid filled capsules should not have more than 2% of moisture exchange with the shell.**   [![gelatin capsules brochure](https://no-cache.hubspot.com/cta/default/7215323/a86c2e8b-555e-4f56-b80b-95e514ea0364.png)](https://cta-redirect.hubspot.com/cta/redirect/7215323/a86c2e8b-555e-4f56-b80b-95e514ea0364) ## **Choose the right method for band sealing**   Liquid filled capsules can be sealed by two different methods: hydro-alcoholic fusion (used for sealing the capsule and avoiding tampering) and banding. The last method involves the cap-body interface, which means banding the capsule with a layer of gelatin. **Be sure to test the quality of your capsules**   ### The most common tests that you should run on your capsules are:   - **Content uniformity** - **Drug content** - **Leak test** - **Seal integrity** - **Weight variation** - **Disintegration** - **Stability** According to[Pharma Trends](https://pharma-trends.com/2020/11/12/liquid-filled-hard-gelatin-capsules-revitalising-pharmaceuticals/), you should be able to use stability testing to test the capsule’s physical characteristics, drug content and drug release after the capsule has been stored in stressed conditions.    ***Keep learning about capsule technology trends...*** - [Gelatin capsules vs. HPMC capsules: What are the differences?](https://blog.capscanada.com/differences-between-gelatin-capsules-and-hpmc-capsules) - [5 Ways to Use G-CAPS® to Differentiate Your Product](https://blog.capscanada.com/5-ways-to-use-g-caps-to-differentiate-your-product) - [Flavored capsules: the next customization level](https://blog.capscanada.com/flavored-capsules-the-next-customization-level)   ## **Why choose liquid formulation LQ-CAPS** **®?**   Lyfe Group’s LQ-CAPS are made specifically to encapsulate liquid formulations. They: - ** Are equally flexible and secure.** - **Address a myriad of liquid-fill formulation issues.** - **Provide a wide range of solutions, from bioavailability challenges to ease of scale-up.** - **Provide faster and more consistent dissolution for optimized absorption.** - **Are a versatile option for manufacturers wishing to formulate smaller products with fewer excipients.** Do you want to know more about liquid hard capsules? Get in touch with an encapsulation expert today.   [![Contact Us](https://no-cache.hubspot.com/cta/default/7215323/7f37dd4c-36a6-44d0-a1d4-56b2c007cad6.png)](https://cta-redirect.hubspot.com/cta/redirect/7215323/7f37dd4c-36a6-44d0-a1d4-56b2c007cad6) CapsCanada is part of [Lyfe Group](https://lyfegroup.com/), a global life sciences organization focused on supporting nutraceutical and pharmaceutical manufacturers worldwide. Through advanced capsule technologies, technical expertise, and integrated supply capabilities, Lyfe Group empowers brands to develop and scale high-quality health products across international markets. Topics: [LQ-CAPS®](https://blog.lyfegroup.com/tag/lq-caps) ## Related blogs [![Capsules for Oil-Based Formulas | CapsCanada](https://blog.lyfegroup.com/hubfs/image-blog-can-capsules-hold-oil-based-formulas.jpg)](https://blog.lyfegroup.com/capsules-for-oil-based-formulas-capscanada) ### [Can Capsules Hold Oil-Based Formulas? Here's What You Need to Know](https://blog.lyfegroup.com/capsules-for-oil-based-formulas-capscanada) Formulating oil-based ingredients in hard capsule form presents unique challenges and opportunities for pharmaceutical... [Read More](https://blog.lyfegroup.com/capsules-for-oil-based-formulas-capscanada) [![Types of sealing for liquid filled capsules - CapsCanada](https://blog.lyfegroup.com/hubfs/sealing-types-for-your-formulation-in-liquid-filled-capsule.png)](https://blog.lyfegroup.com/types-of-sealing-for-liquid-filled-capsules) ### [Sealing Types for Your Formulation in Liquid-Filled Capsule](https://blog.lyfegroup.com/types-of-sealing-for-liquid-filled-capsules) In addition to having multiple advantages such as production efficiency and cost-effectiveness over other medical... [Read More](https://blog.lyfegroup.com/types-of-sealing-for-liquid-filled-capsules) [![Why LFHCs May Be the Best Choice for Your Liquid-Oil Supplements](https://blog.lyfegroup.com/hubfs/01-09.jpg)](https://blog.lyfegroup.com/why-lfhcs-may-be-the-best-choice-for-your-liquid-oil-supplements) ### [Why LFHCs May Be the Best Choice for Your Liquid/Oil Supplements](https://blog.lyfegroup.com/why-lfhcs-may-be-the-best-choice-for-your-liquid-oil-supplements) As the demand for nutritional supplements continues to grow, many brands are looking for ways to improve their... [Read More](https://blog.lyfegroup.com/why-lfhcs-may-be-the-best-choice-for-your-liquid-oil-supplements) [![Aspirin capsule, k caps](https://blog.lyfegroup.com/hubfs/01-03.jpg)](https://blog.lyfegroup.com/liquid-filled-capsules-a-new-way-of-aspirin-delivery-brings-new-opportunities) ### [Liquid-Filled Capsules: A New Way of Aspirin Delivery brings New Opportunities](https://blog.lyfegroup.com/liquid-filled-capsules-a-new-way-of-aspirin-delivery-brings-new-opportunities) This past March, the[FDA approved the first liquid-filled aspirin capsule.](https://www.fiercepharma.com/drug-delivery/fda-approves-first-liquid-filled-aspirin-capsule#:~:text=PLx%20Pharma%20has%20won%20FDA,coated%20and%20immediate%2Drelease%20forms.) PLx introduced a third aspirin option... [Read More](https://blog.lyfegroup.com/liquid-filled-capsules-a-new-way-of-aspirin-delivery-brings-new-opportunities) [![Liquid filled capsules need for fewer required stability studies.](https://blog.lyfegroup.com/hubfs/45-mini-portada.jpg)](https://blog.lyfegroup.com/discover-if-liquid-filled-capsules-are-the-right-delivery-method-for-your-formula) ### [Are Liquid Filled Capsules the Right Delivery Method for Your Formula?](https://blog.lyfegroup.com/discover-if-liquid-filled-capsules-are-the-right-delivery-method-for-your-formula) As the pharmaceutical market continues to develop new and different formulas, delivery methods also evolve . According... [Read More](https://blog.lyfegroup.com/discover-if-liquid-filled-capsules-are-the-right-delivery-method-for-your-formula) [![How to choose a liquid-filled hard capsule manufacturer](https://blog.lyfegroup.com/hubfs/liquid%20filled%20hard%20capsule%20manufacturer%202.jpg)](https://blog.lyfegroup.com/how-to-choose-the-correct-liquid-filled-hard-capsule-manufacturer) ### [How to Choose the Correct Liquid-Filled Hard Capsule Manufacturer](https://blog.lyfegroup.com/how-to-choose-the-correct-liquid-filled-hard-capsule-manufacturer) One of the keys to develop the competitive profile of your business in the pharmaceutical and nutraceutical market is... [Read More](https://blog.lyfegroup.com/how-to-choose-the-correct-liquid-filled-hard-capsule-manufacturer) [![The versatility and value of liquid-filled hard capsules](https://blog.lyfegroup.com/hubfs/liquid-filled%20hard%20capsules%201.jpg)](https://blog.lyfegroup.com/the-versatility-and-value-of-liquid-filled-hard-capsules) ### [The versatility and value of liquid-filled hard capsules](https://blog.lyfegroup.com/the-versatility-and-value-of-liquid-filled-hard-capsules) Even as biologics and gene therapies make headlines, solid dosage forms—tablets and capsules—remain the bread and... [Read More](https://blog.lyfegroup.com/the-versatility-and-value-of-liquid-filled-hard-capsules) [![Liquid-filled hard Capsules can be better than Softgels?](https://blog.lyfegroup.com/hubfs/27-mini-portada-1.jpg)](https://blog.lyfegroup.com/why-liquid-filled-hard-capsules-may-be-a-better-option-than-softgels) ### [Why Liquid-Filled Hard Capsules May Be a Better Option than Softgels](https://blog.lyfegroup.com/why-liquid-filled-hard-capsules-may-be-a-better-option-than-softgels) There are many reasons why a product development team might choose to formulate a drug or supplement for liquid... [Read More](https://blog.lyfegroup.com/why-liquid-filled-hard-capsules-may-be-a-better-option-than-softgels) [![HPAPI’s and two-piece liquid-fill Capsules: the perfect match](https://blog.lyfegroup.com/hubfs/17-mini-portada.jpg)](https://blog.lyfegroup.com/hpapis-and-two-piece-liquid-fill-capsules-the-perfect-match) ### [HPAPI’s and two-piece liquid-fill Capsules: the perfect match](https://blog.lyfegroup.com/hpapis-and-two-piece-liquid-fill-capsules-the-perfect-match) A growing percentage of drug candidates today are highly potent and require special handling during manufacturing and... 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